ISO/TR 16197:2014
Nanotechnologies — Compilation and description of toxicological screening methods for manufactured nanomaterials
ISO/TR 16197:2014 provides a compilation and description of in vitro and in vivo methods that can be useful for the toxicological, including ecotoxicological screening of engineered and manufactured nanomaterials. Toxicological screening tests included in ISO/TR 16197:2014 can be used for such purposes as early decision-making in research and product development, rapid feedback on potential toxicological/safety concerns, or for the preliminary assessment of manufactured nanomaterials. ISO/TR 16197:2014 is divided between screening assays related to humans and screening assays related to the environment. A screening test is a relatively simple, inexpensive test that can be administered easily and provides an indication of potential adverse outcomes and effects on human health or the environment.
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Section sec_1
Section sec_2
Section sec_3
Section sec_3.1
Section sec_3.2
Section sec_3.3
Section sec_3.4
Section sec_3.5
Section sec_3.6
Section sec_3.7
Section sec_3.8
Section sec_3.9
Section sec_3.10
Section sec_4
Section sec_5
Section sec_5.1
Section sec_5.2
Section sec_5.3
Section sec_5.4
Section sec_5.5
Section sec_5.6
Table tab_1
Table tab_2
Section sec_6
Section sec_6.1
Section sec_6.2
Section sec_6.3
Section sec_6.3.1
Section sec_6.3.2
Section sec_6.3.3
Table tab_3
Section sec_6.3.4
Section sec_6.3.4.1
Section sec_6.3.4.2
Section sec_6.3.4.3
Section sec_6.3.4.3.1
Section sec_6.3.4.3.2
Section sec_6.3.4.3.3
Section sec_6.3.5
Section sec_6.3.5.1
Section sec_6.3.5.2
Section sec_6.3.5.3
Section sec_6.3.5.4
Section sec_6.3.6
Section sec_6.3.7
Section sec_6.3.7.1
Section sec_6.3.7.2
Section sec_6.3.7.3
Section sec_6.3.8
Section sec_6.3.9
Section sec_6.4
Section sec_6.4.1
Section sec_6.4.2
Section sec_6.4.3
Section sec_7
Section sec_7.1
Section sec_7.2
Section sec_7.3
Section sec_7.4
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Foreword
Introduction
1 Scope
2 Normative references
3 Terms and definitions
4 Symbols (and abbreviated terms)
5 Background
5.1 Role and relevance of toxicological screening for the safety evaluation of manufactured NMs
5.2 Toxicological screening as part of tiered approaches to toxicological assessment of manufactured NMs
5.3 Discussion of relevant dosing for toxicological screening
5.4 Discussion of the relationship between this Technical Report and ISO/DTR 16196, Compilation and description of sample preparation and dosing methods for manufactured NMs
5.5 Discussion of the relationship between this Technical Report and ISO/TR 13014, Nanotechnologies — Guidance on physico-chemical characterization of engineered nanoscale materials for toxicological assessment
5.6 Review of other relevant international activities and published documents
6 Methods for toxicological screening related to human health
6.1 General
6.2 Positive and negative controls for nanomaterial toxicity testing
6.3 Relevant methods for in vitro toxicological screening of manufactured NMs
6.4 Relevant methods for in vivo toxicological screening of manufactured NMs
7 Methods for toxicological screening related to the environment
7.1 Introduction
7.2 Environmental fate and distribution
7.3 Environmental degradation and transformation
7.4 Environmental biopersistence and bioaccumulation
Bibliography
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Section sec_1
Section sec_2
Section sec_3
Section sec_3.1
Section sec_3.2
Section sec_3.3
Section sec_3.4
Section sec_3.5
Section sec_3.6
Section sec_3.7
Section sec_3.8
Section sec_3.9
Section sec_3.10
Section sec_4
Section sec_5
Section sec_5.1
Section sec_5.2
Section sec_5.3
Section sec_5.4
Section sec_5.5
Section sec_5.6
Table tab_1
Table tab_2
Section sec_6
Section sec_6.1
Section sec_6.2
Section sec_6.3
Section sec_6.3.1
Section sec_6.3.2
Section sec_6.3.3
Table tab_3
Section sec_6.3.4
Section sec_6.3.4.1
Section sec_6.3.4.2
Section sec_6.3.4.3
Section sec_6.3.4.3.1
Section sec_6.3.4.3.2
Section sec_6.3.4.3.3
Section sec_6.3.5
Section sec_6.3.5.1
Section sec_6.3.5.2
Section sec_6.3.5.3
Section sec_6.3.5.4
Section sec_6.3.6
Section sec_6.3.7
Section sec_6.3.7.1
Section sec_6.3.7.2
Section sec_6.3.7.3
Section sec_6.3.8
Section sec_6.3.9
Section sec_6.4
Section sec_6.4.1
Section sec_6.4.2
Section sec_6.4.3
Section sec_7
Section sec_7.1
Section sec_7.2
Section sec_7.3
Section sec_7.4
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Foreword
Introduction
1 Scope
2 Normative references
3 Terms and definitions
4 Symbols (and abbreviated terms)
5 Background
5.1 Role and relevance of toxicological screening for the safety evaluation of manufactured NMs
5.2 Toxicological screening as part of tiered approaches to toxicological assessment of manufactured NMs
5.3 Discussion of relevant dosing for toxicological screening
5.4 Discussion of the relationship between this Technical Report and ISO/DTR 16196, Compilation and description of sample preparation and dosing methods for manufactured NMs
5.5 Discussion of the relationship between this Technical Report and ISO/TR 13014, Nanotechnologies — Guidance on physico-chemical characterization of engineered nanoscale materials for toxicological assessment
5.6 Review of other relevant international activities and published documents
6 Methods for toxicological screening related to human health
6.1 General
6.2 Positive and negative controls for nanomaterial toxicity testing
6.3 Relevant methods for in vitro toxicological screening of manufactured NMs
6.4 Relevant methods for in vivo toxicological screening of manufactured NMs
7 Methods for toxicological screening related to the environment
7.1 Introduction
7.2 Environmental fate and distribution
7.3 Environmental degradation and transformation
7.4 Environmental biopersistence and bioaccumulation
Bibliography